Neuroimmune signaling at the brain borders.
Immunol Rev
; 311(1): 9-25, 2022 10.
Article
em En
| MEDLINE
| ID: mdl-35984321
ABSTRACT
The central nervous system (CNS) has been viewed as an immunologically privileged site, but emerging works are uncovering a large array of neuroimmune interactions primarily occurring at its borders. CNS barriers sites host diverse population of both innate and adaptive immune cells capable of, directly and indirectly, influence the function of the residing cells of the brain parenchyma. These structures are only starting to reveal their role in controlling brain function under normal and pathological conditions and represent an underexplored therapeutic target for the treatment of brain disorders. This review will highlight the development of the CNS barriers to host neuro-immune interactions and emphasize their newly described roles in neurodevelopmental, neurological, and neurodegenerative disorders, particularly for the meninges.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Doenças Neurodegenerativas
Limite:
Humans
Idioma:
En
Revista:
Immunol Rev
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos