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Sesquiterpene coumarins isolated from Ferula bungeana and their anti-neuroinflammatory activities.
Guo, Tingting; Dang, Wen; Zhou, Yaping; Zhou, Di; Meng, Qingqi; Xu, Libin; Chen, Gang; Lin, Bin; Qing, Degang; Sun, Yu; Hou, Yue; Li, Ning.
Afiliação
  • Guo T; School of Traditional Chinese Materia Medica, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Dang W; School of Traditional Chinese Materia Medica, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Zhou Y; School of Traditional Chinese Materia Medica, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Zhou D; School of Traditional Chinese Materia Medica, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Meng Q; College of Life and Health Sciences, Northeastern University, Shenyang 110004, China; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, China.
  • Xu L; College of Life and Health Sciences, Northeastern University, Shenyang 110004, China; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, China.
  • Chen G; School of Traditional Chinese Materia Medica, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Lin B; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Qing D; XinJiang Institute of Chinese Materia Medica and Ethnodrug, Urumqi, China.
  • Sun Y; XinJiang Institute of Chinese Materia Medica and Ethnodrug, Urumqi, China.
  • Hou Y; College of Life and Health Sciences, Northeastern University, Shenyang 110004, China; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, China. Electronic address: houyue@mail.neu.edu.cn.
  • Li N; School of Traditional Chinese Materia Medica, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: liningsypharm@163.com.
Bioorg Chem ; 128: 106102, 2022 11.
Article em En | MEDLINE | ID: mdl-35998519
ABSTRACT
This is the first study to profile natural sesquiterpene coumarins (SCs) in Ferula bungeana, a medicinal plant of the genus Ferula in China. Eight undescribed sesquiterpene coumarins (1-8), along with six known ones (9-14) were obtained from the whole plant of F. bungeana. These unreported SCs (1-8) enriched the structural diversity of natural SCs, especially these with the hydroxy or carbonyl group at C-7' and a hydroperoxy group at C-7' or C-8'. Compounds (9-14) were reported for the first time from this plant. The in vitro anti-neuroinflammatory activity assay showed that compounds 2 and 9 showed stronger inhibitory effect on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced BV-2 microglia, compared with positive control minocycline, and compounds 5 and 10 showed moderate inhibitory effects.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Ferula Idioma: En Revista: Bioorg Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Ferula Idioma: En Revista: Bioorg Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China