ALT, alanine aminotransferase; APAF1, apoptotic peptidase activating factor 1; ASK1, apoptosis signal-regulating kinase 1; AST, aspartate aminotransferase; Apoptosis; BMM, bone marrow-derived macrophage; CXCL-10, C-X-C motif chemokine ligand 10; CYLD, cyclindromatosis; ChIP, chromatin immunoprecipitation; DAMP, damage-associated molecular pattern; DUB, deubiquitinating enzyme; ER, endoplasmic reticulum; ES, embryonic stem; G3BP1; G3BP1, Ras GTPase-activating protein-binding protein 1; GCLC, glutamate-cysteine ligase catalytic subunit; GCLM, glutamate-cysteine ligase regulatory subunit; IHC, immunohistochemistry; INF-ß, interferon-ß; IR, ischaemia/reperfusion; IRF3; IRF3, interferon regulatory factor 3; IRF7, IFN-regulating transcription factor 7; IRI, ischaemia/reperfusion injury; Innate immunity; KO, knockout; LPS, lipopolysaccharide; Liver inflammation; Lyz2, Lysozyme 2; MCP-1, monocyte chemoattractant protein 1; NOX2, NADPH oxidase 2; NOX4, NADPH oxidase 4; NQO1, NAD(P)H quinone dehydrogenase 1; NRF2, nuclear factor (erythroid-derived 2)-like 2; NS, non-specific; Necroptosis; OASL1, 2',5'oligoadenylate synthetase-like 1; PAMP, pathogen-derived molecular pattern; RIPK3, receptor-interacting serine/threonine-protein kinase 3; ROS, reactive oxygen species; STING; STING, stimulator of interferon genes; TBK1, TANK-binding kinase 1; TLR4, Toll-like receptor 4; TNF-α, tumour necrosis factor-alpha; TRX, thioredoxin; TSS, transcription start sites; TXNIP, thioredoxin-interacting protein; TXNIPFL/FL, floxed TXNIP; TXNIPM-KO, myeloid-specific TXNIP KO; UTR, untranslated region; sALT, serum ALT; sAST, serum AST; siRNA, small interfering RNA