Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies.

Scheepers, Cathrine; Kgagudi, Prudence; Mzindle, Nonkululeko; Gray, Elin S; Moyo-Gwete, Thandeka; Lambson, Bronwen E; Oosthuysen, Brent; Mabvakure, Batsirai; Garrett, Nigel J; Abdool Karim, Salim S; Morris, Lynn; Moore, Penny L

Scheepers, Cathrine; Kgagudi, Prudence; Mzindle, Nonkululeko; Gray, Elin S; Moyo-Gwete, Thandeka; Lambson, Bronwen E; Oosthuysen, Brent; Mabvakure, Batsirai; Garrett, Nigel J; Abdool Karim, Salim S; Morris, Lynn; Moore, Penny L.

Afiliação

Scheepers C; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
Kgagudi P; SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.
Mzindle N; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
Gray ES; SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.
Moyo-Gwete T; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
Lambson BE; SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.
Oosthuysen B; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
Mabvakure B; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
Garrett NJ; SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.
Abdool Karim SS; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
Morris L; SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.
Moore PL; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.

PLoS Pathog ; 18(9): e1010450, 2022 09.

Article em En | MEDLINE | ID: mdl-36054228

Assuntos

Vacinas contra a AIDS; Infecções por HIV; HIV-1; Aminoácidos; Anticorpos Monoclonais; Anticorpos Neutralizantes; Anticorpos Amplamente Neutralizantes; Epitopos/química; Epitopos/genética; Anticorpos Anti-HIV; Proteína gp41 do Envelope de HIV; Humanos; Solventes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV-1 / Vacinas contra a AIDS Limite: Humans Idioma: En Revista: PLoS Pathog Ano de publicação: 2022 Tipo de documento: Article País de afiliação: África do Sul

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