The role of exosomes in the molecular mechanisms of metastasis: Focusing on EMT and cancer stem cells.
Life Sci
; 310: 121103, 2022 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-36270429
ABSTRACT
Exosomes are cell-derived small membrane-encapsulated vesicles that transfer biomolecules to surrounding cells. Exosomes play fundamental roles in cell-cell communications. They can also aggravate cancer progression and metastasis. Metastasis is a complicated and multi-serial process that is regulated by various mechanisms. Epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs) are important participants in cancer metastasis. Recent studies demonstrate that exosomes are associated with metastasis by modulating the EMT and the function of CSCs. Accumulating evidence shows that exosomes are implicated in regulating tumor cell metastasis by modulating signaling pathways involved in EMT and CSCs. This review aims to discuss the effect of exosomes on signaling pathways associated with EMT and CSCs, as well as possible therapeutic strategies of exosomes in cancer metastasis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Exossomos
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Life Sci
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Irã