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The 2022 Report on the Human Proteome from the HUPO Human Proteome Project.
Omenn, Gilbert S; Lane, Lydie; Overall, Christopher M; Pineau, Charles; Packer, Nicolle H; Cristea, Ileana M; Lindskog, Cecilia; Weintraub, Susan T; Orchard, Sandra; Roehrl, Michael H A; Nice, Edouard; Liu, Siqi; Bandeira, Nuno; Chen, Yu-Ju; Guo, Tiannan; Aebersold, Ruedi; Moritz, Robert L; Deutsch, Eric W.
Afiliação
  • Omenn GS; University of Michigan, Ann Arbor, Michigan48109, United States.
  • Lane L; Institute for Systems Biology, Seattle, Washington98109, United States.
  • Overall CM; CALIPHO Group, SIB Swiss Institute of Bioinformatics and University of Geneva, 1015Lausanne, Switzerland.
  • Pineau C; University of British Columbia, Vancouver, British ColumbiaV6T 1Z4, Canada.
  • Packer NH; French Institute of Health and Medical Research, 35042RENNESCedexFrance.
  • Cristea IM; Macquarie University, Sydney, New South Wales2109, Australia.
  • Lindskog C; Griffith University's Institute for Glycomics, Sydney, New South Wales2109, Australia.
  • Weintraub ST; Princeton University, Princeton, New Jersey08544, United States.
  • Orchard S; Uppsala University, 752 36Uppsala, Sweden.
  • Roehrl MHA; University of Texas Health Science Center-San Antonio, San Antonio, Texas78229-3900, United States.
  • Nice E; EMBL-EBI, Hinxton, CambridgeshireCB10 1SD, United Kingdom.
  • Liu S; Memorial Sloan Kettering Cancer Center, New York, New York10065, United States.
  • Bandeira N; Monash University, ClaytonVictoria3800, Australia.
  • Chen YJ; BGI Group, Shenzhen518083, P. R. China.
  • Guo T; University of California, San Diego, La Jolla, California92093, United States.
  • Aebersold R; National Taiwan University, Academia Sinica, Nankang, Taipei11529, Taiwan.
  • Moritz RL; Westlake University Guomics Laboratory of Big Proteomic Data, Hangzhou310024, ZhejiangProvinceP. R. China.
  • Deutsch EW; Institute of Molecular Systems Biology in ETH Zurich, 8092Zurich, Switzerland.
J Proteome Res ; 22(4): 1024-1042, 2023 04 07.
Article em En | MEDLINE | ID: mdl-36318223
The 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP) show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 407 (93.2%) of the 19 750 predicted proteins coded in the human genome, a net gain of 50 since 2021 from data sets generated around the world and reanalyzed by the HPP. Conversely, the number of neXtProt PE2, PE3, and PE4 missing proteins has been reduced by 78 from 1421 to 1343. This represents continuing experimental progress on the human proteome parts list across all the chromosomes, as well as significant reclassifications. Meanwhile, applying proteomics in a vast array of biological and clinical studies continues to yield significant findings and growing integration with other omics platforms. We present highlights from the Chromosome-Centric HPP, Biology and Disease-driven HPP, and HPP Resource Pillars, compare features of mass spectrometry and Olink and Somalogic platforms, note the emergence of translation products from ribosome profiling of small open reading frames, and discuss the launch of the initial HPP Grand Challenge Project, "A Function for Each Protein".
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteoma / Proteômica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Proteome Res Assunto da revista: BIOQUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteoma / Proteômica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Proteome Res Assunto da revista: BIOQUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos