Prediction of drug pro-arrhythmic cardiotoxicity using a semi-physiologically based pharmacokinetic model linked to cardiac ionic currents inhibition.

Zhou, Han; Zhang, Zexin; Zhu, Liang; Li, Ping; Hong, Shijin; Liu, Li; Liu, Xiaodong

Zhou, Han; Zhang, Zexin; Zhu, Liang; Li, Ping; Hong, Shijin; Liu, Li; Liu, Xiaodong.

Afiliação

Zhou H; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Zhang Z; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Zhu L; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Li P; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Hong S; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Liu L; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: liulee@cpu.edu.cn.
Liu X; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: xdliu@cpu.edu.cn.

Toxicol Appl Pharmacol ; 457: 116312, 2022 Dec 15.

Article em En | MEDLINE | ID: mdl-36343672

Palavras-chave

Action Potential Duration; Early Afterdepolarizations; Physiologically Based Pharmacokinetic-Pharmacodynamic Model; Tor-ORd Model; Torsades de Pointes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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