Articular Cartilage Imaging in the Context of the Superficial Chondrocyte Spatial Organization (SCSO) as a Surrogate Marker for Functional Pathology.
Methods Mol Biol
; 2598: 265-270, 2023.
Article
em En
| MEDLINE
| ID: mdl-36355297
ABSTRACT
Articular cartilage imaging has undergone tremendous changes and nowadays enables functionally relevant quantitative information useful for detecting the early, preclinical state of articular cartilage degeneration as seen in primary or post-traumatic osteoarthritis (OA/PTOA) to be obtained. In this context, we describe the necessary steps for articular cartilage imaging with the goal to utilize the superficial chondrocyte spatial organization (SCSO) as a score that is responsive to its environment and dynamically changes during the lifetime of an individual and that can be used as a surrogate marker for loss of articular cartilage surface stiffness on the nanoscale.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoartrite
/
Cartilagem Articular
Limite:
Humans
Idioma:
En
Revista:
Methods Mol Biol
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Alemanha