Developmental effects of constitutive mTORC1 hyperactivity and environmental enrichment on structural synaptic plasticity and behaviour in a rat model of autism spectrum disorder.

Granak, Simon; Tuckova, Klara; Kutna, Viera; Vojtechova, Iveta; Bajkova, Laura; Petrasek, Tomas; Ovsepian, Saak V

Granak, Simon; Tuckova, Klara; Kutna, Viera; Vojtechova, Iveta; Bajkova, Laura; Petrasek, Tomas; Ovsepian, Saak V.

Afiliação

Granak S; National Institute of Mental Health, Klecany, Czech Republic.
Tuckova K; Third Faculty of Medicine, Charles University, Prague, Czech Republic.
Kutna V; National Institute of Mental Health, Klecany, Czech Republic.
Vojtechova I; Faculty of Science, Charles University, Prague, Czech Republic.
Bajkova L; National Institute of Mental Health, Klecany, Czech Republic.
Petrasek T; National Institute of Mental Health, Klecany, Czech Republic.
Ovsepian SV; Laboratory of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.

Eur J Neurosci ; 57(1): 17-31, 2023 01.

Article em En | MEDLINE | ID: mdl-36380588

Assuntos

Transtorno do Espectro Autista; Ratos; Animais; Transtorno do Espectro Autista/genética; Transtorno do Espectro Autista/metabolismo; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Células Piramidais/metabolismo; Hipocampo/metabolismo; Plasticidade Neuronal; Modelos Animais de Doenças

Palavras-chave

Eker rats; animal models of autism; cingulate gyrus; dendritic spine; enriched environment; open field test; tuberous sclerosis complex

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno do Espectro Autista Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Eur J Neurosci Assunto da revista: NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: República Tcheca

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