The role of neutrophil extracellular traps in cancer progression, metastasis and therapy.
Exp Hematol Oncol
; 11(1): 99, 2022 Nov 16.
Article
em En
| MEDLINE
| ID: mdl-36384979
ABSTRACT
Neutrophil extracellular traps (NETs) released by activated neutrophils typically consist of DNA-histone complexes and granule proteins. NETs were originally identified as a host defense system against foreign pathogens and are strongly associated with autoimmune diseases. However, a novel and predominant role of NETs in cancer is emerging. Increasing evidence has confirmed that many stimuli can facilitate NET formation in an NADPH oxidase (NOX)-dependent/NOX-independent manner. In cancer, NETs have been linked to cancer progression, metastasis, and cancer-associated thrombosis. In this review, we aimed to summarize the current available knowledge regarding NET formation and focused on the role of NETs in cancer biological behaviors. The potential target for cancer therapy will be further discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Exp Hematol Oncol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China