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The role of neutrophil extracellular traps in cancer progression, metastasis and therapy.
Chen, Yue; Hu, Haoyue; Tan, Songtao; Dong, Qionglan; Fan, Xue; Wang, Yi; Zhang, Huan; He, Jun.
Afiliação
  • Chen Y; Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
  • Hu H; Department of Medical Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Medicine School of University of Electronic Science and Technology, Chengdu, 610041, China.
  • Tan S; West China School of Medicine, Sichuan University, Chengdu, 610041, China.
  • Dong Q; Southeast Medical University, Luzhou, 646099, China.
  • Fan X; Southern Medical University, Guangzhou, 510515, China.
  • Wang Y; Department of Medical Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Medicine School of University of Electronic Science and Technology, Chengdu, 610041, China.
  • Zhang H; Department of Medical Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Medicine School of University of Electronic Science and Technology, Chengdu, 610041, China.
  • He J; Department of Oncology, The Third Hospital of Mianyang (Sichuan Mental Health Center), Mianyang, 621015, China. he-001jun@163.com.
Exp Hematol Oncol ; 11(1): 99, 2022 Nov 16.
Article em En | MEDLINE | ID: mdl-36384979
ABSTRACT
Neutrophil extracellular traps (NETs) released by activated neutrophils typically consist of DNA-histone complexes and granule proteins. NETs were originally identified as a host defense system against foreign pathogens and are strongly associated with autoimmune diseases. However, a novel and predominant role of NETs in cancer is emerging. Increasing evidence has confirmed that many stimuli can facilitate NET formation in an NADPH oxidase (NOX)-dependent/NOX-independent manner. In cancer, NETs have been linked to cancer progression, metastasis, and cancer-associated thrombosis. In this review, we aimed to summarize the current available knowledge regarding NET formation and focused on the role of NETs in cancer biological behaviors. The potential target for cancer therapy will be further discussed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Exp Hematol Oncol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Exp Hematol Oncol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China