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B-cell activating factor (BAFF) and its receptors' expression in pediatric nephrotic syndrome is associated with worse prognosis.
Forero-Delgadillo, Jessica; Ochoa, Vanessa; Restrepo, Jaime M; Torres-Canchala, Laura; Nieto-Aristizábal, Ivana; Ruiz-Ordoñez, Ingrid; Sánchez, Aura; Barrera, María Claudia; Jimenez, Carlos Andrés; Tobón, Gabriel J.
Afiliação
  • Forero-Delgadillo J; Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia.
  • Ochoa V; Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia.
  • Restrepo JM; Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia.
  • Torres-Canchala L; Servicio de Nefrología Pediátrica, Fundación Valle del Lili, Cali, Colombia.
  • Nieto-Aristizábal I; Centro de Investigaciones Clínicas, Fundación Valle del Lili, Cali, Colombia.
  • Ruiz-Ordoñez I; Centro de Investigaciones Clínicas, Fundación Valle del Lili, Cali, Colombia.
  • Sánchez A; Centro de Investigaciones Clínicas, Fundación Valle del Lili, Cali, Colombia.
  • Barrera MC; Servicio de Patología, Fundación Valle del Lili, Cali, Colombia.
  • Jimenez CA; Universidad Icesi, CIRAT: Centro de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Cali, Colombia.
  • Tobón GJ; Servicio de Patología, Fundación Valle del Lili, Cali, Colombia.
PLoS One ; 17(11): e0277800, 2022.
Article em En | MEDLINE | ID: mdl-36399480
AIM: Immune pathogenesis of nephrotic syndrome (NS) is not completely understood. We aimed to evaluate the expression of B-cell activating factor (BAFF) and its receptors in renal samples from pediatric NS patients and its relationship with renal function survival. MATERIALS AND METHODS: We conducted an ambispective study on 33 patients with pediatric NS. Immunohistochemistry for BAFF, TACI, BCMA and BR3 was performed. Markers were evaluated on podocytes and interstitial inflammatory infiltrates (III). We performed Kaplan-Meier curves to describe renal function survival according to markers' expression. RESULTS: Thirty-three NS patients were included. Minimal change disease was seen in 21 (63.6%) patients, and focal segmental glomerulosclerosis in 12 (36.4%). BAFF was found in podocytes (18.2% of samples) and III (36.4% of samples), BAFF-R in one sample, TACI in 4 (podocytes and III), and BCMA in 5 samples of podocytes and 7 of III. BAFF on podocytes and III was associated with worst renal function at follow-up; those patients had 25% probability of having GFR >90 mL/min/1.73m2, versus 84.9% when absent (p = 0.0067). Patients with BAFF in III had 42.9% probability of having GFR>90 mL/min/1.73 m2, versus 94.1% when absent (p = 0.0063). CONCLUSION: BAFF expression in renal biopsies could be a prognostic factor for renal function.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Ativador de Células B / Síndrome Nefrótica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Colômbia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Ativador de Células B / Síndrome Nefrótica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Colômbia