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The role of miRNAs in viral myocarditis, and its possible implication in induction of mRNA-based COVID-19 vaccines-induced myocarditis.
AbdelMassih, Antoine; Agha, Hala; El-Saiedi, Sonia; El-Sisi, Amal; El Shershaby, Meryam; Gaber, Hanya; Ismail, Habiba-Allah; El-Husseiny, Nadine; Amin, Abeer Reda; ElBoraie, Aly; Ayad, Aya; Menshawey, Esraa; Sefein, Fady; Osman, Ibrahim Ihab; Moursi, Mai; Hanafy, Maram; Abdelaziz, Mariam Sherif; Arsanyous, Mariem Badr; Khaled-Ibn-El-Walid, Mariam; Tawfik, Marwa Gamal; Habib, Menna; Mansour, Mina Ehab; Ashraf, Mirette; Khattab, Mohamed Ayman; Alshehry, Nada; Hafez, Nada; ElDeeb, Naheel Essam; Ashraf, Nirvana; Khalil, Noha; AbdElSalam, Noheir Ismail; Shebl, Noura; Hafez, Nouran Gamal Ali; Youssef, Nourhan Hatem; Bahnan, Odette; Ismail, Passant; Kelada, Peter; Menshawey, Rahma; Saeed, Rana; Husseiny, Reem Jalal; Yasser, Reem; Sharaf, Safa; Adel, Veronia; Naeem, Youstina; Nicola, Youstina Nagy Farid; Kamel, Aya; Hozaien, Rafeef; Fouda, Raghda.
Afiliação
  • AbdelMassih A; Pediatric Cardiology Unit, Pediatrics' Department, Faculty of Medicine, Cairo University, P.O. Box 12411, Cairo, Egypt.
  • Agha H; Pediatric Cardio-Oncology Clinic, Children Cancer Hospital of Egypt, Cairo, Egypt.
  • El-Saiedi S; Pediatric Cardiology Unit, Pediatrics' Department, Faculty of Medicine, Cairo University, P.O. Box 12411, Cairo, Egypt.
  • El-Sisi A; Pediatric Cardiology Unit, Pediatrics' Department, Faculty of Medicine, Cairo University, P.O. Box 12411, Cairo, Egypt.
  • El Shershaby M; Pediatric Cardiology Unit, Pediatrics' Department, Faculty of Medicine, Cairo University, P.O. Box 12411, Cairo, Egypt.
  • Gaber H; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Ismail HA; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • El-Husseiny N; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Amin AR; Faculty of Dentistry, Cairo University, Cairo, Egypt.
  • ElBoraie A; Pixagon Graphic Design Agency, Cairo, Egypt.
  • Ayad A; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Menshawey E; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Sefein F; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Osman II; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Moursi M; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Hanafy M; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Abdelaziz MS; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Arsanyous MB; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Khaled-Ibn-El-Walid M; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Tawfik MG; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Habib M; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Mansour ME; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Ashraf M; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Khattab MA; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Alshehry N; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Hafez N; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • ElDeeb NE; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Ashraf N; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Khalil N; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • AbdElSalam NI; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Shebl N; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Hafez NGA; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Youssef NH; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Bahnan O; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Ismail P; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Kelada P; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Menshawey R; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Saeed R; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Husseiny RJ; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Yasser R; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Sharaf S; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Adel V; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Naeem Y; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Nicola YNF; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Kamel A; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Hozaien R; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Fouda R; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
Bull Natl Res Cent ; 46(1): 267, 2022.
Article em En | MEDLINE | ID: mdl-36415483
ABSTRACT

Background:

Several reports of unheeded complications secondary to the current mass international rollout of SARS-COV-2 vaccines, one of which is myocarditis occurring with the FDA fully approved vaccine, Pfizer, and others. Main body of the abstract Certain miRNAs (non-coding RNA sequences) are involved in the pathogenesis in viral myocarditis, and those miRNAs are interestingly upregulated in severe COVID-19. We hypothesize that the use of mRNA-based vaccines may be triggering the release of host miRNAs or that trigger the occurrence of myocarditis. This is based on the finding of altered host miRNA expression promoting virus-induced myocarditis. Short

conclusion:

In conclusion, miRNAs are likely implicated in myocarditis associated with mRNA vaccines. Our hypothesis suggests the use of miRNA as a biomarker for the diagnosis of mRNA vaccine-induced myocarditis. Additionally, the interplay between viral miRNA and the host immune system could alter inflammatory profiles, hence suggesting the use of therapeutic inhibition to prevent such complications.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Bull Natl Res Cent Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Egito
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Bull Natl Res Cent Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Egito