[Analysis of withdrawal status and influencing factors in patients receiving methadone maintenance treatment in Hubei province].
Zhonghua Liu Xing Bing Xue Za Zhi
; 43(10): 1645-1650, 2022 Oct 10.
Article
em Zh
| MEDLINE
| ID: mdl-36456498
ABSTRACT
Objective:
To analyze the withdrawal in patients receiving methadone maintenance treatment (MMT) and its related influencing factors in Hubei province.Methods:
The patients receiving MMT in clinics in Hubei province were selected from June 2006 to December 2021. The general demographic data, drug abuse history, and MMT information were collected. The survival data of patients with MMT were analyzed by the Kaplan-Meier method, and the Cox proportional hazards model was used for multivariate analysis.Results:
A total of 26 716 patients receiving MMT were included in this study, and the gender ratio between men and women was 3.34â¶1(20 557â¶6 159). The duration of MMT was 0.01-15.72 years, and the median duration was 2.21 (95%CI 2.16-2.26) years. At the end of the follow-up, the withdrawal proportion was 86.75% (23 175/26 716). MMT's 0-year, 2-year, 4-year, 9-year and 14-year cumulative probabilities appeared as 67.61%, 40.24%, 30.03%, 15.49% and 6.56%, respectively. Results from the Cox proportional hazards regression model showed that the factors of the withdrawal risk were higher in patients receiving MMT, including minority nationality (HR=1.66,95%CI1.52-1.82), having jobs (HR=1.05, 95%CI1.01-1.08), no history of compulsory isolation or detoxification (HR=1.04, 95%CI1.01-1.09) and the enrollment in 2016-2021 (HR=1.46,95%CI1.35-1.58). The factors of the withdrawal risk were lower in patients receiving MMT, including 60-year-olds or above (HR=0.56,95%CI0.42-0.75), college degree or above education level (HR=0.83, 95%CI0.75-0.91), outpatient services of other cities (HR=0.90, 95%CI0.87-0.93), drug use for 20 years or more (HR=0.72, 95%CI0.66-0.80), 90 mg or more per daily dosage (HR=0.73,95%CI0.69-0.78) and the enrollment in 2011-2015 (HR=0.93,95%CI0.89-0.97).Conclusions:
The withdrawal proportions of patients receiving MMT were high in Hubei province. The withdrawal influencing factors were complex. The daily dose was an essential factor that can be intervened under the safe MMT condition, and a higher dose should be appropriately prescribed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tratamento de Substituição de Opiáceos
/
Metadona
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Zhonghua Liu Xing Bing Xue Za Zhi
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China