Arterial hypertension in systemic sclerosis.
Postepy Dermatol Alergol
; 39(5): 865-871, 2022 Oct.
Article
em En
| MEDLINE
| ID: mdl-36457666
ABSTRACT
Introduction:
Arterial hypertension (AH) is common in systemic connective tissue diseases.Aim:
To evaluate the incidence of AH in patients with systemic sclerosis (SSc) and to present clinical characteristics of the group diagnosed with AH. Material andmethods:
The study involved 108 patients with SSc divided into two groups with AH (+) - 45 and AH (-) - 63. Moreover, the serological profile, scleroderma renal crisis, involvement of internal organs and mortality were determined. The kidney function was assessed based on creatinine concentration and the estimated glomerular filtration rate (eGFR).Results:
AH was diagnosed in 47/108 SSc patients (41.7%). The age difference among patients was statistically significant and was higher in the AH (+) SSc group (p = 0.026). The incidences of oesophageal involvement (p = 0.011), digital ulcerations (p = 0.017), and mortality (p = 0.019) were found to be significantly higher in the AH (+) SSc group. Scleroderma renal crisis was observed in 9/108 patients (8.3%). The incidence of chronic kidney disease (CKD) was higher in the AH (+) SSc group, both of stage 2 (p = 0.013) and 3 (p = 0.07). Stages 4 and 5 of CKD were found only in the group with AH. Moreover, this group had a higher incidence of elevated uric acid (p = 0.007).Conclusions:
AH is relatively common in patients with SSc and is associated with a significantly more severe course of the disease and higher frequency of renal involvement.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Postepy Dermatol Alergol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Polônia