Thymol Ameliorates <i>Aspergillus fumigatus</i> Keratitis by Downregulating the TLR4/ MyD88/ NF-kB/ IL-1ß Signal Expression and Reducing Necroptosis and Pyroptosis.

Wang, Limei; Yan, Haijing; Chen, Xiaomeng; Han, Lin; Liu, Guibo; Yang, Hua; Lu, Danli; Liu, Wenting; Che, Chengye

Thymol Ameliorates Aspergillus fumigatus Keratitis by Downregulating the TLR4/ MyD88/ NF-kB/ IL-1ß Signal Expression and Reducing Necroptosis and Pyroptosis.

Wang, Limei; Yan, Haijing; Chen, Xiaomeng; Han, Lin; Liu, Guibo; Yang, Hua; Lu, Danli; Liu, Wenting; Che, Chengye.

Afiliação

Wang L; Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003, P.R. China.
Yan H; Department of Ophthalmology, Qingdao Women and Children's Hospital, Qingdao, Shandong Province 266034, P.R. China.
Chen X; Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003, P.R. China.
Han L; Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003, P.R. China.
Liu G; Gout Laboratory, the Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003, P.R. China.
Yang H; Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003, P.R. China.
Lu D; Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003, P.R. China.
Liu W; Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003, P.R. China.
Che C; Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003, P.R. China.

J Microbiol Biotechnol ; 33(1): 43-50, 2023 Jan 28.

Article em En | MEDLINE | ID: mdl-36517045

Assuntos

Aspergilose; Ceratite; Animais; Camundongos; Anti-Inflamatórios/uso terapêutico; Aspergilose/tratamento farmacológico; Aspergilose/metabolismo; Aspergillus fumigatus/genética; Aspergillus fumigatus/metabolismo; Modelos Animais de Doenças; Ceratite/tratamento farmacológico; Ceratite/metabolismo; Ceratite/microbiologia; Camundongos Endogâmicos C57BL; Fator 88 de Diferenciação Mieloide/genética; Fator 88 de Diferenciação Mieloide/metabolismo; Necroptose; NF-kappa B/genética; NF-kappa B/metabolismo; Piroptose; Timol/farmacologia; Timol/uso terapêutico; Receptor 4 Toll-Like/genética; Receptor 4 Toll-Like/metabolismo

Palavras-chave

A. fumigatus keratitis; Thymol; inflammation; necroptosis; pyroptosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aspergilose / Ceratite Limite: Animals Idioma: En Revista: J Microbiol Biotechnol Ano de publicação: 2023 Tipo de documento: Article

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