Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II.

Smith, Joshua D; Brawley, Jhonnathan; Bordenave, Kate C; Olsen, Ryan K; Intasiri, Amarawan; Cremo, Christine R; Bell, Thomas W

Smith, Joshua D; Brawley, Jhonnathan; Bordenave, Kate C; Olsen, Ryan K; Intasiri, Amarawan; Cremo, Christine R; Bell, Thomas W.

Afiliação

Smith JD; Department of Pharmacology, University of Nevada, School of Medicine, Reno, NV, 89557-0318, USA.
Brawley J; Department of Chemistry, University of Nevada, Reno, NV, 89557-0216, USA.
Bordenave KC; Department of Pharmacology, University of Nevada, School of Medicine, Reno, NV, 89557-0318, USA.
Olsen RK; Department of Chemistry, University of Nevada, Reno, NV, 89557-0216, USA.
Intasiri A; Department of Chemistry, University of Nevada, Reno, NV, 89557-0216, USA.
Cremo CR; Department of Pharmacology, University of Nevada, School of Medicine, Reno, NV, 89557-0318, USA. Electronic address: cremo@unr.edu.
Bell TW; Department of Chemistry, University of Nevada, Reno, NV, 89557-0216, USA. Electronic address: twb@unr.edu.

Eur J Med Chem ; 247: 115008, 2023 Feb 05.

Article em En | MEDLINE | ID: mdl-36543032

Assuntos

4-Hidroxicumarinas; Miosina Tipo II; Miosinas; Isoformas de Proteínas; Adenosina Trifosfatases

Palavras-chave

Docking; Homology model; Hydroxyquinoline imine; Myosin inhibitor; Selectivity; Structure-activity relationships

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Miosina Tipo II / 4-Hidroxicumarinas Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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