MiR-100 rs1834306 A>G Increases Biliary Atresia Risk in Southern Han Chinese Children.
Biomed Res Int
; 2023: 4835839, 2023.
Article
em En
| MEDLINE
| ID: mdl-36644163
ABSTRACT
Background:
Biliary atresia (BA) is a type of severe cholestatic childhood disease that may have a genetic component. miR-100 plays a key role in regulating cell apoptosis, proliferation, and inflammatory reactions. A single-nucleotide polymorphism in miR-100 has been proven to modulate susceptibility to various diseases.Methods:
We conducted a case-control retrospective study to explore the correlation between miR-100 gene polymorphism (rs1834306 A>G) and biliary atresia susceptibility in 484 Chinese patients and 1445 matched control subjects.Results:
Our results showed that rs1834306 A>G was correlated with a significantly increased risk for BA (GG vs. AA adjusted odds ratio (OR) = 1.44, 95%confidence interval (CI) = 1.02-2.03, p = 0.041; and GG vs. AA/AG adjusted OR = 1.39, 95%CI = 1.02-1.89, p = 0.036).Conclusions:
Our results showed that the rs1834306 A>G polymorphism is associated with an increased risk for BA and contributes to BA susceptibility.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Atresia Biliar
/
MicroRNAs
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Biomed Res Int
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China