Neurophysiological changes induced by 5-HT reuptake inhibitors in rabbits.
Farmaco Sci
; 42(7): 505-12, 1987 Jul.
Article
em En
| MEDLINE
| ID: mdl-3666124
ABSTRACT
The EEGraphic, behavioural and autonomic changes induced by the administration of some inhibitors of serotonin (5-HT) reuptake were evaluated in the rabbit. The drugs examined were Alaproclate (Ala), Citalopram (Cit), Fluoxetine (Fluo), Fluvoxamine (Fluvo), Indalpine (Ind), Zimelidine (Zim). It seems that all these drugs would act exclusively or prevalently on 5-HT uptake. The changes of the parameters studied were not homogeneous. Some of these drugs (Cit, Zim) induced an EEGraphic and behavioural "arousal" pattern, others (Fluo, Fluvo) a "slow wave sleep" one, others (Ala, Ind) a biphasic one (alteration of the two above-mentioned patterns). The possible hypotheses subtending these data are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antagonistas da Serotonina
/
Sistema Nervoso Autônomo
Limite:
Animals
Idioma:
En
Revista:
Farmaco Sci
Ano de publicação:
1987
Tipo de documento:
Article
País de afiliação:
Itália