Efficacy of Dabrafenib and Trametinib in a Patient with Squamous-Cell Carcinoma, with Mutation p.D594G in <i>BRAF</i> and p.R461* in <i>NF1</i> Genes-A Case Report with Literature Review.

Grenda, Anna; Krawczyk, Pawel; Targowska-Duda, Katarzyna M; Kieszko, Robert; Pasnik, Iwona; Milanowski, Janusz

Efficacy of Dabrafenib and Trametinib in a Patient with Squamous-Cell Carcinoma, with Mutation p.D594G in BRAF and p.R461* in NF1 Genes-A Case Report with Literature Review.

Grenda, Anna; Krawczyk, Pawel; Targowska-Duda, Katarzyna M; Kieszko, Robert; Pasnik, Iwona; Milanowski, Janusz.

Afiliação

Grenda A; Department of Pneumonology, Oncology and Allergology, Medical University in Lublin, Jaczewskiego 8, 20-090 Lublin, Poland.
Krawczyk P; Department of Pneumonology, Oncology and Allergology, Medical University in Lublin, Jaczewskiego 8, 20-090 Lublin, Poland.
Targowska-Duda KM; Department of Biopharmacy, Medical University in Lublin, Chodzki 4a, 20-093 Lublin, Poland.
Kieszko R; Department of Pneumonology, Oncology and Allergology, Medical University in Lublin, Jaczewskiego 8, 20-090 Lublin, Poland.
Pasnik I; Department of Clinical Pathomorphology, Medical University in Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.
Milanowski J; Department of Pneumonology, Oncology and Allergology, Medical University in Lublin, Jaczewskiego 8, 20-090 Lublin, Poland.

Int J Mol Sci ; 24(2)2023 Jan 07.

Article em En | MEDLINE | ID: mdl-36674722

Assuntos

Carcinoma Pulmonar de Células não Pequenas; Carcinoma de Células Escamosas; Neoplasias Pulmonares; Masculino; Humanos; Idoso; Genes da Neurofibromatose 1; Carcinoma Pulmonar de Células não Pequenas/genética; Proteínas Proto-Oncogênicas B-raf/metabolismo; Piridonas/farmacologia; Pirimidinonas/farmacologia; Proteínas Serina-Treonina Quinases/genética; Carcinoma de Células Escamosas/genética; MAP Quinases Reguladas por Sinal Extracelular/genética; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Mutação; Serina/genética; Inibidores de Proteínas Quinases/farmacologia; Inibidores de Proteínas Quinases/uso terapêutico

Palavras-chave

BRAF mutation; FANCC mutation; NF1 mutation; dabrafenib; squamous-cell carcinoma; trametinib

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Escamosas / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Aged / Humans / Male Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Polônia

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