EBV LMP1-C terminal binding affibody molecule downregulates MEK/ERK/p90RSK pathway and inhibits the proliferation of nasopharyngeal carcinoma cells in mouse tumor xenograft models.

Guo, Yanru; Kamara, Saidu; Zhang, Jing; Wen, He; Zheng, Maolin; Liu, Ying; Zhou, Luqi; Chen, Jun; Zhu, Shanli; Zhang, Lifang

Guo, Yanru; Kamara, Saidu; Zhang, Jing; Wen, He; Zheng, Maolin; Liu, Ying; Zhou, Luqi; Chen, Jun; Zhu, Shanli; Zhang, Lifang.

Afiliação

Guo Y; Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Kamara S; Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhang J; Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Wen H; Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zheng M; Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Liu Y; Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhou L; Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Chen J; Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhu S; Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhang L; Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Front Cell Infect Microbiol ; 12: 1078504, 2022.

Article em En | MEDLINE | ID: mdl-36683690

Assuntos

Infecções por Vírus Epstein-Barr; Carcinoma Nasofaríngeo; Neoplasias Nasofaríngeas; Animais; Humanos; Camundongos; Linhagem Celular Tumoral; Proliferação de Células; Infecções por Vírus Epstein-Barr/tratamento farmacológico; Herpesvirus Humano 4/metabolismo; Sistema de Sinalização das MAP Quinases; Quinases de Proteína Quinase Ativadas por Mitógeno/metabolismo; Carcinoma Nasofaríngeo/tratamento farmacológico; Carcinoma Nasofaríngeo/virologia; Neoplasias Nasofaríngeas/tratamento farmacológico; Neoplasias Nasofaríngeas/virologia; Recidiva Local de Neoplasia; Proteínas Quinases S6 Ribossômicas 90-kDa/metabolismo; Proteínas Quinases S6 Ribossômicas 90-kDa/farmacologia; Proteínas Quinases S6 Ribossômicas 90-kDa/uso terapêutico; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

EBV; LMP1; affibody molecules; nasopharyngeal carcinoma; targeted therapy

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Nasofaríngeas / Infecções por Vírus Epstein-Barr / Carcinoma Nasofaríngeo Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Front Cell Infect Microbiol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google