Dietary intake of total, heme and non-heme iron and the risk of colorectal cancer in a European prospective cohort study.
Br J Cancer
; 128(8): 1529-1540, 2023 04.
Article
em En
| MEDLINE
| ID: mdl-36759722
ABSTRACT
BACKGROUND:
Iron is an essential micronutrient with differing intake patterns and metabolism between men and women. Epidemiologic evidence on the association of dietary iron and its heme and non-heme components with colorectal cancer (CRC) development is inconclusive.METHODS:
We examined baseline dietary questionnaire-assessed intakes of total, heme, and non-heme iron and CRC risk in the EPIC cohort. Sex-specific multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were computed using Cox regression. We modelled substitution of a 1 mg/day of heme iron intake with non-heme iron using the leave one-out method.RESULTS:
Of 450,105 participants (318,680 women) followed for 14.2 ± 4.0 years, 6162 (3511 women) developed CRC. In men, total iron intake was not associated with CRC risk (highest vs. lowest quintile, HRQ5vs.Q10.88; 95%CI0.73, 1.06). An inverse association was observed for non-heme iron (HRQ5vs.Q10.80, 95%CI0.67, 0.96) whereas heme iron showed a non-significant association (HRQ5vs.Q11.10; 95%CI0.96, 1.27). In women, CRC risk was not associated with intakes of total (HRQ5vs.Q11.11, 95%CI0.94, 1.31), heme (HRQ5vs.Q10.95; 95%CI0.84, 1.07) or non-heme iron (HRQ5vs.Q11.03, 95%CI0.88, 1.20). Substitution of heme with non-heme iron demonstrated lower CRC risk in men (HR0.94; 95%CI 0.89, 0.99).CONCLUSIONS:
Our findings suggest potential sex-specific CRC risk associations for higher iron consumption that may differ by dietary sources.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Heme
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
Idioma:
En
Revista:
Br J Cancer
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
França