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A Novel Role of the Two-Component System Response Regulator UvrY in Enterohemorrhagic Escherichia coli O157:H7 Pathogenicity Regulation.
Wu, Pan; Wang, Qian; Yang, Qian; Feng, Xiaohui; Liu, Xingmei; Sun, Hongmin; Yan, Jun; Kang, Chenbo; Liu, Bin; Liu, Yutao; Yang, Bin.
Afiliação
  • Wu P; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China.
  • Wang Q; Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China.
  • Yang Q; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China.
  • Feng X; Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China.
  • Liu X; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China.
  • Sun H; Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China.
  • Yan J; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China.
  • Kang C; Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China.
  • Liu B; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China.
  • Liu Y; Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China.
  • Yang B; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China.
Int J Mol Sci ; 24(3)2023 Jan 24.
Article em En | MEDLINE | ID: mdl-36768620
ABSTRACT
Enterohemorrhagic Escherichia coli (EHEC) O157H7 is an important human pathogen causing severe diseases, such as hemorrhagic colitis and lethal hemolytic uremic syndrome. The signal-sensing capability of EHEC O157H7 at specific host colonization sites via different two-component systems (TCSs) is closely related to its pathogenicity during infection. However, the types of systems involved and the regulatory mechanisms are not fully understood. Here, we investigated the function of the TCS BarA/UvrY regulator UvrY in the pathogenicity regulation of EHEC O157H7. Our results showed that UvrY acts as a positive regulator of EHEC O157H7 for cellular adherence and mouse colonization through the transcriptional activation of the locus for enterocyte effacement (LEE) pathogenic genes. Furthermore, this regulation is mediated by the LEE island master regulator, Ler. Our results highlight the significance of UvrY in EHEC O157H7 pathogenicity and underline the unknown importance of BarA/UvrY in colonization establishment and intestinal adaptability during infection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escherichia coli O157 / Proteínas de Escherichia coli / Infecções por Escherichia coli Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escherichia coli O157 / Proteínas de Escherichia coli / Infecções por Escherichia coli Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China