2-[(2-Amino-6-methylpyrimidin-4-yl)sulfanyl]-N-arylacetamides: Discovery of a new class of anti-tubercular agents and prospects for their further structural modification.

Erkin, Andrei V; Serebryakov, Evgeny B; Krutikov, Viktor I

Erkin, Andrei V; Serebryakov, Evgeny B; Krutikov, Viktor I.

Afiliação

Erkin AV; Department of Chemistry and Technology of Synthetic Biologically Active Compounds, Saint Petersburg State Institute of Technology (Technical University), Saint Petersburg 190013, Russia. Electronic address: anerkin@yandex.ru.
Serebryakov EB; Chemical Analysis and Materials Research Centre, Saint Petersburg State University, Saint Petersburg 198504, Russia.
Krutikov VI; Department of Chemistry and Technology of Synthetic Biologically Active Compounds, Saint Petersburg State Institute of Technology (Technical University), Saint Petersburg 190013, Russia.

Bioorg Med Chem Lett ; 83: 129189, 2023 03 01.

Article em En | MEDLINE | ID: mdl-36805047

Assuntos

Antibacterianos; Bactérias; Antibacterianos/farmacologia; Antituberculosos/farmacologia; Simulação de Acoplamento Molecular; Relação Estrutura-Atividade; Acetamidas/química; Acetamidas/farmacologia; Pirimidinas/química; Pirimidinas/farmacologia

Palavras-chave

Anti-tubercular agents; CMAS1; Docking study; Molecular similarity; Pyrimidines

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Antibacterianos Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article

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