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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome is common in post-acute sequelae of SARS-CoV-2 infection (PASC): Results from a post-COVID-19 multidisciplinary clinic.
Bonilla, Hector; Quach, Tom C; Tiwari, Anushri; Bonilla, Andres E; Miglis, Mitchell; Yang, Phillip C; Eggert, Lauren E; Sharifi, Husham; Horomanski, Audra; Subramanian, Aruna; Smirnoff, Liza; Simpson, Norah; Halawi, Houssan; Sum-Ping, Oliver; Kalinowski, Agnieszka; Patel, Zara M; Shafer, Robert William; Geng, Linda N.
Afiliação
  • Bonilla H; Department of Medicine, Stanford University, Stanford, CA, United States.
  • Quach TC; Department of Medicine, Stanford University, Stanford, CA, United States.
  • Tiwari A; Department of Medicine, Stanford University, Stanford, CA, United States.
  • Bonilla AE; Department of Molecular, Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, United States.
  • Miglis M; Department of Medicine, Stanford University, Stanford, CA, United States.
  • Yang PC; Department of Medicine, Stanford University, Stanford, CA, United States.
  • Eggert LE; Department of Medicine, Stanford University, Stanford, CA, United States.
  • Sharifi H; Department of Medicine, Stanford University, Stanford, CA, United States.
  • Horomanski A; Department of Medicine, Stanford University, Stanford, CA, United States.
  • Subramanian A; Department of Medicine, Stanford University, Stanford, CA, United States.
  • Smirnoff L; Department of Medicine, Stanford University, Stanford, CA, United States.
  • Simpson N; Department of Medicine, Stanford University, Stanford, CA, United States.
  • Halawi H; Department of Medicine, Stanford University, Stanford, CA, United States.
  • Sum-Ping O; Department of Medicine, Stanford University, Stanford, CA, United States.
  • Kalinowski A; Department of Medicine, Stanford University, Stanford, CA, United States.
  • Patel ZM; Department of Medicine, Stanford University, Stanford, CA, United States.
  • Shafer RW; Department of Medicine, Stanford University, Stanford, CA, United States.
  • Geng LN; Department of Medicine, Stanford University, Stanford, CA, United States.
Front Neurol ; 14: 1090747, 2023.
Article em En | MEDLINE | ID: mdl-36908615
Background: The global prevalence of PASC is estimated to be present in 0·43 and based on the WHO estimation of 470 million worldwide COVID-19 infections, corresponds to around 200 million people experiencing long COVID symptoms. Despite this, its clinical features are not well-defined. Methods: We collected retrospective data from 140 patients with PASC in a post-COVID-19 clinic on demographics, risk factors, illness severity (graded as one-mild to five-severe), functional status, and 29 symptoms and principal component symptoms cluster analysis. The Institute of Medicine (IOM) 2015 criteria were used to determine the Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) phenotype. Findings: The median age was 47 years, 59.0% were female; 49.3% White, 17.2% Hispanic, 14.9% Asian, and 6.7% Black. Only 12.7% required hospitalization. Seventy-two (53.5%) patients had no known comorbid conditions. Forty-five (33.9%) were significantly debilitated. The median duration of symptoms was 285.5 days, and the number of symptoms was 12. The most common symptoms were fatigue (86.5%), post-exertional malaise (82.8%), brain fog (81.2%), unrefreshing sleep (76.7%), and lethargy (74.6%). Forty-three percent fit the criteria for ME/CFS, majority were female, and obesity (BMI > 30 Kg/m2) (P = 0.00377895) and worse functional status (P = 0.0110474) were significantly associated with ME/CFS. Interpretations: Most PASC patients evaluated at our clinic had no comorbid condition and were not hospitalized for acute COVID-19. One-third of patients experienced a severe decline in their functional status. About 43% had the ME/CFS subtype.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: Front Neurol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: Front Neurol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos