Fibrillin-1 mutation contributes to Marfan syndrome by inhibiting Cav1.2-mediated cell proliferation in vascular smooth muscle cells.

Lin, Wenfeng; Xiong, Jiaqi; Jiang, Yefan; Liu, Hao; Bian, Jinhui; Wang, Juejin; Shao, Yongfeng; Ni, Buqing

Lin, Wenfeng; Xiong, Jiaqi; Jiang, Yefan; Liu, Hao; Bian, Jinhui; Wang, Juejin; Shao, Yongfeng; Ni, Buqing.

Afiliação

Lin W; Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Xiong J; Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Jiang Y; Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Liu H; Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Bian J; Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Wang J; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, China.
Shao Y; Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Ni B; Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Channels (Austin) ; 17(1): 2192377, 2023 12.

Article em En | MEDLINE | ID: mdl-36972239

Assuntos

Canais de Cálcio Tipo L; Fibrilina-1; Síndrome de Marfan; Humanos; Proliferação de Células; Fibrilina-1/genética; Fibrilina-1/metabolismo; Síndrome de Marfan/genética; Síndrome de Marfan/metabolismo; Músculo Liso Vascular/metabolismo; Mutação; Miócitos de Músculo Liso/metabolismo; Fator de Crescimento Transformador beta1/genética; Fator de Crescimento Transformador beta1/metabolismo; Canais de Cálcio Tipo L/metabolismo

Palavras-chave

Cav1.2; FBN1; Marfan Syndrome; cell cycle; cell proliferation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canais de Cálcio Tipo L / Fibrilina-1 / Síndrome de Marfan Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Channels (Austin) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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