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Porphyromonas gingivalis promotes malignancy and chemo-resistance via GSK3ß-mediated mitochondrial oxidative phosphorylation in human esophageal squamous cell carcinoma.
Liu, Yiwen; Zhou, Fuyou; Yang, Haijun; Zhang, Zheyuan; Zhang, Jiahao; He, Keyao; Qian, Mengfan; Li, Ruonan; Sun, Wei; Dai, Ningtao; Li, Junkuo; Guo, Yibo; Kong, Jinyu; Gao, Shegan.
Afiliação
  • Liu Y; School of Information Engineering, Henan University of Science and Technology, Luoyang 471023, China; College of Clinical Medicine, The First Affiliated Hospital, Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Henan Key Laboratory of Cancer Epigenetics, Henan Univ
  • Zhou F; The Affiliated Anyang Tumor Hospital, Henan Key Laboratory of Precision Prevention and Treatment of Esophageal Cancer, Henan University of Science and Technology, Anyang 455000, China.
  • Yang H; The Affiliated Anyang Tumor Hospital, Henan Key Laboratory of Precision Prevention and Treatment of Esophageal Cancer, Henan University of Science and Technology, Anyang 455000, China.
  • Zhang Z; College of Clinical Medicine, The First Affiliated Hospital, Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Henan Key Laboratory of Cancer Epigenetics, Henan University of Science and Technology, Luoyang 471003, China.
  • Zhang J; Department of Thoracic Surgery, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang 453003, China.
  • He K; Department of Thoracic Surgery, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang 453003, China.
  • Qian M; College of Clinical Medicine, The First Affiliated Hospital, Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Henan Key Laboratory of Cancer Epigenetics, Henan University of Science and Technology, Luoyang 471003, China.
  • Li R; College of Clinical Medicine, The First Affiliated Hospital, Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Henan Key Laboratory of Cancer Epigenetics, Henan University of Science and Technology, Luoyang 471003, China.
  • Sun W; College of Clinical Medicine, The First Affiliated Hospital, Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Henan Key Laboratory of Cancer Epigenetics, Henan University of Science and Technology, Luoyang 471003, China.
  • Dai N; The Affiliated Anyang Tumor Hospital, Henan Key Laboratory of Precision Prevention and Treatment of Esophageal Cancer, Henan University of Science and Technology, Anyang 455000, China.
  • Li J; The Affiliated Anyang Tumor Hospital, Henan Key Laboratory of Precision Prevention and Treatment of Esophageal Cancer, Henan University of Science and Technology, Anyang 455000, China.
  • Guo Y; College of Clinical Medicine, The First Affiliated Hospital, Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Henan Key Laboratory of Cancer Epigenetics, Henan University of Science and Technology, Luoyang 471003, China.
  • Kong J; College of Clinical Medicine, The First Affiliated Hospital, Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Henan Key Laboratory of Cancer Epigenetics, Henan University of Science and Technology, Luoyang 471003, China.
  • Gao S; School of Information Engineering, Henan University of Science and Technology, Luoyang 471023, China; College of Clinical Medicine, The First Affiliated Hospital, Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Henan Key Laboratory of Cancer Epigenetics, Henan Univ
Transl Oncol ; 32: 101656, 2023 Jun.
Article em En | MEDLINE | ID: mdl-36989676
Our prior studies have confirmed that long-term colonization of Porphyromonas gingivalis (Pg) and overexpression of the inflammatory factor glycogen synthase kinase 3ß (GSK3ß) promote the malignant evolution of esophageal squamous cell carcinoma (ESCC). We aimed to investigate the functional mechanism by which Pg could promote ESCC malignancy and chemo-resistance through GSK3ß-mediated mitochondrial oxidative phosphorylation (mtOXPHOS), and the clinical implications. The effects of Pg and GSK3ß on mtOXPHOS, malignant behaviors and response to paclitaxel and cisplatin treatment of ESCC cells were evaluated by in vitro and in vivo studies. The results showed that Pg induced high expression of the GSK3ß protein in ESCC cells and promoted the progression and chemo-resistance via GSK3ß-mediated mtOXPHOS in human ESCC. Then, Pg infection and the expression of GSK3ß, SIRT1 and MRPS5 in ESCC tissues were detected, and the correlations between each index and postoperative survival of ESCC patients were analysed. The results showed that Pg-positive ESCC patients with high-expression of GSK3ß, SIRT1 and MRPS5 have significant short postoperative survival. In conclusion, we demonstrated that the effective removal of Pg and inhibition of its promotion of GSK3ß-mediated mtOXPHOS may provide a new strategy for ESCC treatment and new insights into the aetiology of ESCC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Transl Oncol Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Transl Oncol Ano de publicação: 2023 Tipo de documento: Article