Methodology for Effect-Based Identification of Bioconcentratable Endocrine Disrupting Chemicals (EDCs) in Water: Establishment, Validation, and Application.
Environ Sci Technol
; 57(15): 6284-6295, 2023 04 18.
Article
em En
| MEDLINE
| ID: mdl-37013483
ABSTRACT
Since the wide occurrence of endocrine disrupting chemicals (EDCs) in water is associated with various adverse effects in aquatic organisms, it is urgent to identify key bioconcentratable EDCs. Currently, bioconcentration is generally ignored during the identification of key EDCs. Thus, a methodology for effect-based identification of bioconcentratable EDCs was established in Microcosm, validated in the field, and applied to typical surface water in Taihu Lake. In Microcosm, an inverted U-shaped relationship between logBCFs and logKows was observed for typical EDCs, with medium hydrophobic EDCs (3 ≤ logKow ≤ 7) exhibiting the greatest bioconcentration potentials. On this basis, enrichment methods for bioconcentratable EDCs were established using POM and LDPE, which better fitted the bioconcentration characteristics and enabled the enrichment of 71 ± 8% and 69 ± 6% bioconcentratable compounds. The enrichment methods were validated in the field, where LDPE exhibited a more significant correlation with the bioconcentration characteristics than POM, with mean correlation coefficients of 0.36 and 0.15, respectively, which was selected for further application. By application of the new methodology in Taihu Lake, 7 EDCs were prioritized from 79 identified EDCs as key bioconcentratable EDCs on consideration of their great abundance, bioconcentration potentials, and anti-androgenic potencies. The established methodology could support the evaluation and identification of bioconcentratable contaminants.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poluentes Químicos da Água
/
Disruptores Endócrinos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Revista:
Environ Sci Technol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China