[Compounds with anti-gastric secretion and antiulcer activity. V. Derivatives of 3,3,4a,6,7,11b-hexahydro-2H,5H-benzo [1,4]cyclohep[1,2-b][1,4]-oxazine and related products]. / Composti ad attività antisecretiva gastrica ed antiulcera. Nota V. Derivati di 3,4,4a,6,7,11b-esaidro-2H, 5H-benzo[1,4]cicloept-[1,2-b][1,4]ossazine e prodotti correlati.
Farmaco Sci
; 41(3): 229-56, 1986 Mar.
Article
em It
| MEDLINE
| ID: mdl-3709787
ABSTRACT
A series of hexahydrobenzo[3,4]cyclohept[1,2-b][1,4]oxazines, with different substituents at the benzene and oxazine rings and nitrogen atom, was synthetized. The diastereomers and enantiomers of the unsubstituted compound and the related derivatives hexahydrobenzo[5,6] and exahydrobenzo[6,7]cyclohept[1,2-b][1,4]oxazine, hexahydro[1]benzoxepine and hexahydro[1]benzothiepin[5,4-b][1,4]oxazine, octahydrobenzo[3,4]cyclohept[1,2-b][1,4]diazine were also prepared. Some of these compounds inhibited at low doses gastric secretion in pylorus-ligated rats and antagonized ulcers in pylorus-ligated rats plus acetylsalicylic acid and in cold+restraint-stressed rats. When the most active compounds were tested on cats with Heidenhain pouch, they induced unwanted side effects that ruled out further development of these chemical series.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxazinas
/
Antiulcerosos
Limite:
Animals
Idioma:
It
Revista:
Farmaco Sci
Ano de publicação:
1986
Tipo de documento:
Article