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The Role of Surveillance Inspections in Reducing False-Positives of SARS-CoV-2 Omicron Variants during the COVID-19 Epidemic.
Liu, Li-Li; Zheng, Yu-Hong; Zhang, You-Quan; Lin, Jin-Piao; Luo, Zhi-Lin; Yu, Liu-Min; Gao, Shi-Hua; Chen, Falin.
Afiliação
  • Liu LL; Department of Center of Clinical Laboratory, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
  • Zheng YH; Xiamen Clinical Laboratory Quality Control Center, Xiamen, China.
  • Zhang YQ; Department of Laboratory, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, China.
  • Lin JP; Department of Laboratory, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Quanzhou, China.
  • Luo ZL; Department of Laboratory, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • Yu LM; Department of Laboratory, The First Hospital of Putian City, Putian, China.
  • Gao SH; Department of Laboratory, Affiliated Hospital of Putian University, Putian, China.
  • Chen F; The Affiliated Hospital of Fujian Medical University of First Hospital of Nanping, Nanping, China.
Can J Infect Dis Med Microbiol ; 2023: 8508975, 2023.
Article em En | MEDLINE | ID: mdl-37124122
Objective: This study aims to assess the effectiveness of surveillance inspections conducted by the provincial health committee in Quanzhou city during a COVID-19 outbreak in reducing false-positive results in SARS-CoV-2 RT-PCR assays. Method: The team conducted on-site inspections of laboratories that participated in mass screening, recording any violations of rules. Results: The positive cases in five rounds of mass screening were 23, 173, and 4 in Licheng District, Fengze District, and Luojang District, respectively. The false-positive rates in the five rounds of mass screening were 0.0099%, 0.0063%, 0.0018%, 0.0006%, and 0%, respectively. The study also recorded that the number of violations in the seven selected laboratories was 36, 68, 69, 42, 60, 54 and 47. The corresponding false-positive rates were 0.0012%, 0.0060%, 0.0082%, 0.0032%, 0.0060%, 0.0027%, and 0.0021%, respectively. The study found a positive correlation between false-positive rates and the number of violations (r = 0.905, P=0.005), and an inverse correlation between false-positive rates and the frequency of surveillance inspections (r = -0.950, P < 0.001). Conclusion: Daily surveillance inspection in laboratories can remind laboratories to strictly comply with standard procedures, focus on laboratory quality control, and reduce the occurrence of false-positive cases in SARS-CoV-2 nucleic acid tests to some extent. This study recommends that government decision-making departments establish policies and arrange experts to conduct daily surveillance inspections to improve laboratory quality control.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Screening_studies Idioma: En Revista: Can J Infect Dis Med Microbiol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Screening_studies Idioma: En Revista: Can J Infect Dis Med Microbiol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China