Effective inhibition of breast cancer stem cell properties by quercetin-loaded solid lipid nanoparticles via reduction of Smad2/Smad3 phosphorylation and ß-catenin signaling pathway in triple-negative breast cancer.

Hatami, Mahdi; Kouchak, Maryam; Kheirollah, Alireza; Khorsandi, Layasadat; Rashidi, Mojtaba

Hatami, Mahdi; Kouchak, Maryam; Kheirollah, Alireza; Khorsandi, Layasadat; Rashidi, Mojtaba.

Afiliação

Hatami M; Cellular and Molecular Research Center, Medical Basic Sciences Research Institution, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Kouchak M; Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Pharmaceutics, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Kheirollah A; Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Khorsandi L; Cellular and Molecular Research Center, Medical Basic Sciences Research Institution, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Rashidi M; Cellular and Molecular Research Center, Medical Basic Sciences Research Institution, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: ms_rashidi6

Biochem Biophys Res Commun ; 664: 69-76, 2023 07 05.

Article em En | MEDLINE | ID: mdl-37141640

Assuntos

Neoplasias de Mama Triplo Negativas; beta Catenina; Humanos; beta Catenina/metabolismo; Quercetina/farmacologia; Quercetina/uso terapêutico; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Neoplasias de Mama Triplo Negativas/metabolismo; Linhagem Celular Tumoral; Fosforilação; Transdução de Sinais; Células-Tronco Neoplásicas/metabolismo; Transição Epitelial-Mesenquimal; Movimento Celular; Proteína Smad3/metabolismo; Proteína Smad2/metabolismo

Palavras-chave

Cancer stem cell (CSC); Epithelial-mesenchymal transition (EMT); Invasive; Quercetin; Solid lipid nanoparticles (SLN)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta Catenina / Neoplasias de Mama Triplo Negativas Limite: Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Irã

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