Studies on tableting properties of lactose. Part III. The consolidation behaviour of sieve fractions of crystalline alpha-lactose monohydrate.
Pharm Weekbl Sci
; 8(2): 145-50, 1986 Apr 25.
Article
em En
| MEDLINE
| ID: mdl-3714438
ABSTRACT
The consolidation and compaction behaviour of sieve fractions of crystalline alpha-lactose monohydrate were studied. From mercury porosimetry measurements tablet pore surface areas were derived. At a certain compaction load it appeared that tablets compressed from small particles were generally stronger and showed a larger surface area than compacts prepared from coarse sieve fractions. By plotting compact strength against pore surface area, a unique linear relationship was obtained. From these results it can be concluded that the actual tablet surface area, being a function of both the initial particle size and applied compaction pressure, is responsible for the compact strength.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lactose
Idioma:
En
Revista:
Pharm Weekbl Sci
Ano de publicação:
1986
Tipo de documento:
Article