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Rational design of 4-((6-phenoxypyrimidin-4-yl)amino)-N-(4-(piperazin-1-yl)phenyl)-1H-pyrazole-3-carboxamide (LT-540-717) as orally bioavailable FLT3 inhibitor.
Zhi, Yanle; Li, Hongmei; Yang, Pei; Jin, Qiaomei; Yao, Chao; Li, Baoquan; Ling, Jun; Guo, Hao; Li, Tonghui; Jin, Jianlin; Wang, Yue; Chen, Yadong; Lu, Tao; Lu, Shuai.
Afiliação
  • Zhi Y; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, PR China.
  • Li H; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Yang P; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Jin Q; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Yao C; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Li B; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Ling J; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Guo H; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Li T; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Jin J; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Wang Y; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China. Electronic address: zwy_1115@126.com.
  • Chen Y; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China. Electronic address: chenyadong@gmail.com.
  • Lu T; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China. Electronic address: lut163@163.com.
  • Lu S; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China. Electronic address: lu_shuai@cpu.edu.cn.
Eur J Med Chem ; 256: 115448, 2023 Aug 05.
Article em En | MEDLINE | ID: mdl-37163951
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Tirosina Quinase 3 Semelhante a fms Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Tirosina Quinase 3 Semelhante a fms Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article