Molecular epidemiology, clinical features and significance of Shiga toxin detection from routine testing of gastroenteritis specimens.
Pathology
; 55(5): 656-662, 2023 Aug.
Article
em En
| MEDLINE
| ID: mdl-37271611
ABSTRACT
After introduction of faecal multiplex PCR that includes targets for stx1 and stx2 genes, we found stx genes were detected in 120 specimens from 111 patients over a 31-month period from 2018-2020 from a total of 14,179 separate tests performed. The proportion of stx1 only vs stx2 only vs stx1 and stx2 was 35%, 22% and 42%, respectively. There were 54 specimens which were culture positive, with 33 different serotypes identified, the predominant serotype being O157H7 (19%). Eighty-two patients had clinical data available; we found a high rate of fever (35%), bloody diarrhoea (34%), acute kidney injury (27%), hospital admission (80%) and detection of faecal co-pathogens (23%). Only one patient developed haemolytic uraemic syndrome. We found no significant association with stx genotype and any particular symptom or complication. We found a significant association of serotypes O157H7 and O26H11 with bloody stool, but no significant association with any other symptom or complication.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Escherichia coli O157
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Infecções por Escherichia coli
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Escherichia coli Shiga Toxigênica
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Gastroenterite
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Síndrome Hemolítico-Urêmica
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
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Screening_studies
Limite:
Humans
Idioma:
En
Revista:
Pathology
Ano de publicação:
2023
Tipo de documento:
Article