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Photodynamic immunotherapy using ADU-S100-modified nanoparticles to treat triple-negative breast cancer.
Ge, Tong; Ge, Wenshu; Zhang, Ludan; Yu, Guohui; Li, Yi; Sun, Lisha; Dong, Fan; Yao, Zhi; Shi, Lei; Wang, Yuguang.
Afiliação
  • Ge T; Department of Immunology, Key Laboratory of Immune Microenvironment & Disease of the Educational Ministry of China, Tianjin Key Laboratory of Cellular & Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
  • Ge W; Center of Digital Dentistry/Department of Prosthodontics, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital & Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, NHC Research Center of E
  • Zhang L; Center of Digital Dentistry/Department of Prosthodontics, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital & Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, NHC Research Center of E
  • Yu G; Department of Immunology, Key Laboratory of Immune Microenvironment & Disease of the Educational Ministry of China, Tianjin Key Laboratory of Cellular & Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
  • Li Y; Department of Immunology, Key Laboratory of Immune Microenvironment & Disease of the Educational Ministry of China, Tianjin Key Laboratory of Cellular & Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
  • Sun L; Center of Digital Dentistry/Department of Prosthodontics, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital & Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, NHC Research Center of E
  • Dong F; Center of Digital Dentistry/Department of Prosthodontics, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital & Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, NHC Research Center of E
  • Yao Z; Department of Immunology, Key Laboratory of Immune Microenvironment & Disease of the Educational Ministry of China, Tianjin Key Laboratory of Cellular & Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
  • Shi L; Department of Immunology, Key Laboratory of Immune Microenvironment & Disease of the Educational Ministry of China, Tianjin Key Laboratory of Cellular & Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
  • Wang Y; Center of Digital Dentistry/Department of Prosthodontics, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital & Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, NHC Research Center of E
Nanomedicine (Lond) ; 18(9): 755-767, 2023 04.
Article em En | MEDLINE | ID: mdl-37306248
ABSTRACT

Aim:

STING agonists in immunotherapy show great promise and are currently in clinical trials. Combinations of STING agonists with other therapies remain underexplored. This study aimed to combine STING agonist-mediated immunotherapy with photodynamic therapy to treat breast cancer.

Methods:

STING agonist (ADU-S100)-functionalized porphyrin-based nanoparticles (NP-AS) were prepared and their antitumor properties in terms of cell apoptosis/necrosis and immune activation in triple-negative breast cancer were evaluated.

Results:

NP-AS induced tumor cell apoptosis/necrosis, activated the innate immune response and exhibited useful antitumor effects.

Conclusion:

NP-AS effectively treated breast cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Neoplasias de Mama Triplo Negativas / Neoplasias Limite: Humans Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Neoplasias de Mama Triplo Negativas / Neoplasias Limite: Humans Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China