Modification, by a poly I:C injection, of organ distribution of intravenously injected murine lymphoma cells and of blood coagulability.

ABSTRACT

51Cr-or 111In-labelled murine lymphoma cells were injected IV in control and poly IC-treated mice. The organ distribution (lung, spleen, liver) of radioactivity was measured 2 h after injection. The results showed that if cell injection was performed 1 day after poly IC treatment, the modifications of organ distribution did not fit with the expectations from a reinforcement of the NK function in vivo. In NK-suppressed mice, poly IC affected the distribution of radioactivity in spleen and liver in the same manner as in normal mice, suggesting that the action does not entirely depend on the NK system. Additionally to that, poly IC injections affected coagulability of the plasma from treated mice, by prolonging the coagulation time. It is concluded that poly IC exerts a complex action on circulation and fixation of lymphoma cells.