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Subspace partitioning in the human prefrontal cortex resolves cognitive interference.
Weber, Jan; Iwama, Gabriela; Solbakk, Anne-Kristin; Blenkmann, Alejandro O; Larsson, Pal G; Ivanovic, Jugoslav; Knight, Robert T; Endestad, Tor; Helfrich, Randolph.
Afiliação
  • Weber J; Hertie Institute for Clinical Brain Research, Center for Neurology, University Medical Center Tübingen, 72076 Tübingen, Germany.
  • Iwama G; International Max Planck Research School for the Mechanisms of Mental Function and Dysfunction, University of Tübingen, 72076 Tübingen, Germany.
  • Solbakk AK; Hertie Institute for Clinical Brain Research, Center for Neurology, University Medical Center Tübingen, 72076 Tübingen, Germany.
  • Blenkmann AO; International Max Planck Research School for the Mechanisms of Mental Function and Dysfunction, University of Tübingen, 72076 Tübingen, Germany.
  • Larsson PG; Department of Psychology, University of Oslo, 0373 Oslo, Norway.
  • Ivanovic J; RITMO Centre for Interdisciplinary Studies in Rhythm, Time and Motion, University of Oslo, 0373 Oslo, Norway.
  • Knight RT; Department of Neurosurgery, Oslo University Hospital, 0372 Oslo, Norway.
  • Endestad T; Department of Neuropsychology, Helgeland Hospital, 8657 Mosjøen, Norway.
  • Helfrich R; Department of Psychology, University of Oslo, 0373 Oslo, Norway.
Proc Natl Acad Sci U S A ; 120(28): e2220523120, 2023 07 11.
Article em En | MEDLINE | ID: mdl-37399398
The human prefrontal cortex (PFC) constitutes the structural basis underlying flexible cognitive control, where mixed-selective neural populations encode multiple task features to guide subsequent behavior. The mechanisms by which the brain simultaneously encodes multiple task-relevant variables while minimizing interference from task-irrelevant features remain unknown. Leveraging intracranial recordings from the human PFC, we first demonstrate that competition between coexisting representations of past and present task variables incurs a behavioral switch cost. Our results reveal that this interference between past and present states in the PFC is resolved through coding partitioning into distinct low-dimensional neural states; thereby strongly attenuating behavioral switch costs. In sum, these findings uncover a fundamental coding mechanism that constitutes a central building block of flexible cognitive control.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Pré-Frontal / Cognição Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Pré-Frontal / Cognição Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha