Residues from Homologous Transmembrane Helices 4 and 10 Are Critical for P-Glycoprotein (ABCB1)-Mediated Drug Transport.

Rahman, Hadiar; Ware, Mark J; Sajid, Andaleeb; Lusvarghi, Sabrina; Durell, Stewart R; Ambudkar, Suresh V

Rahman, Hadiar; Ware, Mark J; Sajid, Andaleeb; Lusvarghi, Sabrina; Durell, Stewart R; Ambudkar, Suresh V.

Afiliação

Rahman H; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4256, USA.
Ware MJ; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4256, USA.
Sajid A; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4256, USA.
Lusvarghi S; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4256, USA.
Durell SR; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4256, USA.
Ambudkar SV; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4256, USA.

Cancers (Basel) ; 15(13)2023 Jul 01.

Article em En | MEDLINE | ID: mdl-37444569

Palavras-chave

ABC transporter; P-glycoprotein; chemoresistance; drug transport; molecular dynamics simulations; multidrug resistance; mutational analysis; structure and function; transmembrane helices

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cancers (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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