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Father's care uniquely influences male neurodevelopment.
Danoff, Joshua S; Ramos, Erin N; Hinton, Taylor D; Perkeybile, Allison M; Graves, Andrew J; Quinn, Graham C; Lightbody-Cimer, Aaron R; Gordevicius, Juozas; Milciute, Milda; Brooke, Robert T; Carter, C Sue; Bales, Karen L; Erisir, Alev; Connelly, Jessica J.
Afiliação
  • Danoff JS; Department of Psychology, University of Virginia, Charlottesville, VA 22904.
  • Ramos EN; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA 22904.
  • Hinton TD; Department of Psychology, University of Virginia, Charlottesville, VA 22904.
  • Perkeybile AM; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA 22904.
  • Graves AJ; Department of Psychology, University of Virginia, Charlottesville, VA 22904.
  • Quinn GC; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA 22904.
  • Lightbody-Cimer AR; Department of Psychology, University of Virginia, Charlottesville, VA 22904.
  • Gordevicius J; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA 22904.
  • Milciute M; Department of Psychology, University of Virginia, Charlottesville, VA 22904.
  • Brooke RT; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA 22904.
  • Carter CS; Department of Psychology, University of Virginia, Charlottesville, VA 22904.
  • Bales KL; Department of Psychology, University of Virginia, Charlottesville, VA 22904.
  • Erisir A; Epigenetic Clock Development Foundation, Torrance, CA 90502.
  • Connelly JJ; Epigenetic Clock Development Foundation, Torrance, CA 90502.
Proc Natl Acad Sci U S A ; 120(31): e2308798120, 2023 08.
Article em En | MEDLINE | ID: mdl-37487074
ABSTRACT
Mammalian infants depend on parental care for survival, with numerous consequences for their behavioral development. We investigated the epigenetic and neurodevelopmental mechanisms mediating the impact of early biparental care on development of alloparenting behavior, or caring for offspring that are not one's own. We find that receiving high parental care early in life leads to slower epigenetic aging of both sexes and widespread male-specific differential expression of genes related to synaptic transmission and autism in the nucleus accumbens. Examination of parental care composition indicates that high-care fathers promote a male-specific increase in excitatory synapses and increases in pup retrieval behavior as juveniles. Interestingly, females raised by high-care fathers have the opposite behavioral response and display fewer pup retrievals. These results support the concept that neurodevelopmental trajectories are programmed by different features of early-life parental care and reveal that male neurodevelopmental processes are uniquely sensitive to care by fathers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Pai Limite: Animals / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Pai Limite: Animals / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article