Sustained Effects of Capsaicin Infusion into the Oropharynx on Swallowing in Perfused Rats.
Laryngoscope
; 134(1): 305-314, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37503765
ABSTRACT
OBJECTIVES:
To examine the sustained effects of oropharyngeal capsaicin stimulation on the regulation of swallowing, we recorded the swallowing-related nerve activities during continuous infusion of capsaicin solution into the oropharynx.METHODS:
In 33 in situ perfused brainstem preparation of rats, we recorded the activities of the vagus, hypoglossal, and phrenic nerves during fictive swallowing. The interburst intervals (IBIs) of the swallowing-related nerves during sequential pharyngeal swallowing (sPSW) elicited by electrical stimulation of the superior laryngeal nerve (SLN) during concurrent capsaicin stimulation of 10, 1, and 0.1 µM (n = 28) were compared with those during oropharyngeal infusion of saline (control) (n = 5).RESULTS:
The IBIs during SLN-induced sPSW were reduced at 5 min after initiation of continuous infusion of 10 and 1 µM capsaicin solution. The IBIs showed significant decreases to -25.8 ± 6.9%, -25.9 ± 5.3, -18.3 ± 3.7, and -12.0 ± 1.6 at 30 min following 1 µM capsaicin stimulation at SLN stimulus conditions at 5 Hz of 1.2 times threshold, 10 Hz of 40 µA, 5 Hz of 60 µA, and 10 Hz of 60 µA, respectively. Continuous capsaicin stimulation of 0.1 µM solution did not show significant sustained effects.CONCLUSION:
Pharmacological stimulation of capsaicin could provide time-dependent effects on the likelihood of swallowing, particularly subserving sustained facilitation of swallowing reflex with appropriate concentration of capsaicin. LEVEL OF EVIDENCE NA Laryngoscope, 134305-314, 2024.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Capsaicina
/
Deglutição
Limite:
Animals
Idioma:
En
Revista:
Laryngoscope
Assunto da revista:
OTORRINOLARINGOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão