Enhanced Expression of p53 and Suppression of PI3K/Akt/mTOR by Three Red Sea Algal Extracts: Insights on Their Composition by LC-MS-Based Metabolic Profiling and Molecular Networking.

Fahmy, Nouran M; El-Din, Mariam I Gamal; Salem, Maha M; Rashedy, Sarah H; Lee, Gyu Sung; Jang, Yoon Seo; Kim, Ki Hyun; Kim, Chung Sub; El-Shazly, Mohamed; Fayez, Shaimaa

Fahmy, Nouran M; El-Din, Mariam I Gamal; Salem, Maha M; Rashedy, Sarah H; Lee, Gyu Sung; Jang, Yoon Seo; Kim, Ki Hyun; Kim, Chung Sub; El-Shazly, Mohamed; Fayez, Shaimaa.

Afiliação

Fahmy NM; Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, Egypt.
El-Din MIG; Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, Egypt.
Salem MM; Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta 31527, Egypt.
Rashedy SH; National Institute of Oceanography and Fisheries (NIOF), Cairo 11516, Egypt.
Lee GS; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Jang YS; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Kim KH; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Kim CS; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea.
El-Shazly M; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Fayez S; Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, Egypt.

Mar Drugs ; 21(7)2023 Jul 17.

Article em En | MEDLINE | ID: mdl-37504935

Assuntos

Proteínas Proto-Oncogênicas c-akt; Transdução de Sinais; Humanos; Proteínas Proto-Oncogênicas c-akt/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteína Supressora de Tumor p53/metabolismo; Cromatografia Líquida; Oceano Índico; Proliferação de Células; Espectrometria de Massas em Tandem; Serina-Treonina Quinases TOR/metabolismo; Células MCF-7; Apoptose; Linhagem Celular Tumoral

Palavras-chave

HR-LC/MS/MS; PI3K/Akt/mTOR; apoptosis; brown algae; cytotoxicity; protein kinases

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteínas Proto-Oncogênicas c-akt Limite: Humans Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Egito

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google