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Dual RNase activity of IRE1 as a target for anticancer therapies.
Bartoszewska, Sylwia; Slawski, Jakub; Collawn, James F; Bartoszewski, Rafal.
Afiliação
  • Bartoszewska S; Department of Inorganic Chemistry, Medical University of Gdansk, Gdansk, Poland.
  • Slawski J; Department of Biophysics, Faculty of Biotechnology, University of Wroclaw, F. Joliot-Curie 14a Street, 50-383, Wroclaw, Poland.
  • Collawn JF; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
  • Bartoszewski R; Department of Biophysics, Faculty of Biotechnology, University of Wroclaw, F. Joliot-Curie 14a Street, 50-383, Wroclaw, Poland. rafal.bartoszewski@uwr.edu.pl.
J Cell Commun Signal ; 17(4): 1145-1161, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37721642
The unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular homeostasis and cell survival. During unmitigated stress conditions, however, UPR activation signaling changes to promote cell death through apoptosis. Interestingly, cancer cells take advantage of this pathway to facilitate survival and avoid apoptosis even during prolonged cell stress conditions. Here, we discuss different signaling pathways associated with UPR and focus specifically on one of the ER signaling pathways activated during UPR, inositol-requiring enzyme 1α (IRE1). The rationale is that the IRE1 pathway is associated with cell fate decisions and recognized as a promising target for cancer therapeutics. Here we discuss IRE1 inhibitors and how they might prove to be an effective cancer therapeutic.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Cell Commun Signal Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Polônia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Cell Commun Signal Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Polônia