A method for in vivo evaluation of α-glucosidase inhibition using Drosophila.
MethodsX
; 11: 102373, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37744885
ABSTRACT
The development of α-glucosidase inhibitors is essential for the prevention of type II diabetes. Previous research has investigated in vitro inhibition using isolated α-glucosidase, which may not accurately reflect physical processes. The method presented in this study aims to establish a rapid and inexpensive in vivo method to study the inhibition of α-glucosidase activity using Drosophila as a model organism. This method can be used to calculate the IC50 value of compounds of interest for inhibition of α-glucosidase activity. The method established in this study can be used for in vivo screening of anti-diabetic compounds. â¢A rapid and inexpensive in vivo method to study the inhibition of α-glucosidase activity.â¢This method can be used to calculate the IC50 value of compounds of interest for inhibition of α-glucosidase activity.â¢This is a useful method for in vivo screening of anti-diabetic compounds.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
MethodsX
Ano de publicação:
2023
Tipo de documento:
Article