Female genital schistosomiasis, human papilloma virus infection, and cervical cancer in rural Madagascar: a cross sectional study.
Infect Dis Poverty
; 12(1): 89, 2023 Sep 25.
Article
em En
| MEDLINE
| ID: mdl-37749705
ABSTRACT
BACKGROUND:
Women's health in resource-limited settings can benefit from the integrated management of high-burden diseases, such as female genital schistosomiasis (FGS) and human papilloma virus (HPV)-related cervical cancer. In schistosomiasis-endemic countries such as Madagascar, data on FGS and HPV prevalence are lacking as well as preventive measures for both conditions. This study aims to estimate the prevalence of FGS and HPV in rural Madagascar, and to examine associated risk factors to identify opportunities for improving women's health.METHODS:
After initial community outreach activities, interested women aged 18-49 years were recruited consecutively in 2021 at three primary health care centers in the district of Marovoay. FGS was detected by colposcopy. Colposcopy images were double-blind reviewed by two independent specialists. A Luminex bead-based assay was performed on cervical vaginal lavage specimens for HPV typing. Crude (CPR) and adjusted prevalence ratios (APR) of associations between selected factors and FGS and HPV positivity were estimated using univariable and multivariable binary Poisson regression with 95% confidence intervals (CIs).RESULTS:
Among 500 women enrolled, 302 had complete information on FGS and HPV diagnosis, and were thus eligible for analysis. Within the sample, 189 (62.6%, 95% CI 56.9-68.1) cases of FGS were detected. A total of 129 women (42.7%, 95% CI 37.1-48.5) tested positive for HPV. In total, 80 women (26.5%, 95% CI 21.6-31.8]) tested positive for both conditions. No association was observed between FGS and HPV positivity, while previous pregnancy (APR = 0.65, 95% CI 0.43-0.78) and older age (APR = 0.59, 95% CI 0.42-0.81) are showing a negative association with HPV infection compared to no previous pregnancy and younger age groups.CONCLUSIONS:
The results of the study show that FGS and HPV are highly prevalent in rural Madagascar. The concurrent prevalence of these two conditions requires urgent adaptations of public health strategies to improve women's health, such as integrated services at primary level of care.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Colo do Útero
/
Infecções por Papillomavirus
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prevalence_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Female
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Humans
/
Pregnancy
País/Região como assunto:
Africa
Idioma:
En
Revista:
Infect Dis Poverty
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Alemanha