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Identifying immune checkpoint-related lncRNA biomarkers for immunotherapy response and prognosis in cancers.
Gao, Yue; Wang, Xinyue; Dong, Longlong; Qu, Changfan; Lu, Qianyi; Wang, Peng; Xin, Mengyu; Zheng, Wen; Liu, Chenyu; Ning, Shangwei.
Afiliação
  • Gao Y; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Wang X; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Dong L; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Qu C; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Lu Q; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Wang P; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Xin M; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Zheng W; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Liu C; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
  • Ning S; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China. ningsw@ems.hrbmu.edu.cn.
Sci Data ; 10(1): 663, 2023 09 28.
Article em En | MEDLINE | ID: mdl-37770497
ABSTRACT
Long non-coding RNAs (lncRNAs) could modulate expression of immune checkpoints (ICPs) in tumor-immune. However, precise functions in immunity and potential for predicting ICP inhibitors (ICI) response have been described for only a few lncRNAs. Here, a multiple-step pipeline was developed to identify cancer- and immune-context ICP and lncRNA cooperative regulation pairs (ICPaLncCRPs) across cancers. Immune-related ICPs and lncRNAs were extracted follow immune cell lines and immunologic constant of rejection groups. ICPaLncCRP networks were constructed, which likely to modulate tumor-immune by specific patterns. Common and specific hub ICPaLncs such as MIR155HG, TRG-AS1 and PCED1B-AS1 maybe play central roles in prognosis and circulating. Moreover, these hub ICPaLncs were significantly correlated with immune cell infiltration based on bulk and single-cell RNA sequencing data. Some ICPaLncCRPs such as IDO1-MIR155HG could predict three- and five-year prognosis of melanoma in two independent datasets. We also validated that some ICPaLncCRPs could effectively predict ICI-response follow six independent datasets. Collectively, this study will enhance our understanding of lncRNA functions and accelerate discovery of lncRNA-based biomarkers in ICI treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Longo não Codificante / Melanoma Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Sci Data Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Longo não Codificante / Melanoma Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Sci Data Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China