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Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN).
Hsiao, Wendy; Li, Yimei; Getz, Kelly; Cao, Lusha; Krause, Edward; Ramos, Mark; Lee, Judy; Gramatges, Maria Monica; Rabin, Karen R; Scheurer, Michael E; Aplenc, Richard; Denburg, Michelle; Miller, Tamara P.
Afiliação
  • Hsiao W; Division of Nephrology, Children's Hospital Los Angeles, Los Angeles, California, USA.
  • Li Y; Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Getz K; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Cao L; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Krause E; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Ramos M; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Lee J; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Gramatges MM; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Rabin KR; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Scheurer ME; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Aplenc R; Aflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
  • Denburg M; Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA.
  • Miller TP; Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Pediatr Blood Cancer ; 70(12): e30696, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37776085
ABSTRACT
Children with acute leukemia are at increased risk of kidney injury. Using electronic health record data from three centers between 2010 and 2018, this study retrospectively described acute kidney injury (AKI) and chronic kidney disease (CKD) prevalence in children with acute lymphoblastic or myeloid leukemia (ALL, AML) using Common Terminology Criteria for Adverse Events (CTCAE) and Kidney Disease Improving Global Outcomes (KDIGO) definitions. AKI during therapy was 25% (ALL) and 32% (AML) using CTCAE, versus 84% (ALL) and 74% (AML) using KDIGO. CKD prevalence was low and Grade 1/Stage 2. Further investigation is needed to optimally define kidney injury in acute leukemia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Insuficiência Renal Crônica / Injúria Renal Aguda Tipo de estudo: Risk_factors_studies Limite: Child / Humans Idioma: En Revista: Pediatr Blood Cancer Assunto da revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Insuficiência Renal Crônica / Injúria Renal Aguda Tipo de estudo: Risk_factors_studies Limite: Child / Humans Idioma: En Revista: Pediatr Blood Cancer Assunto da revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos