Exosomes from adipose-derived mesenchymal stem cells improve liver fibrosis by regulating the miR-20a-5p/TGFBR2 axis to affect the p38 MAPK/NF-&#954;B pathway.

Gan, Lihong; Zheng, Li; Yao, Ling; Lei, Ling; Huang, Yaqin; Zeng, Zhiping; Fang, Nian

Exosomes from adipose-derived mesenchymal stem cells improve liver fibrosis by regulating the miR-20a-5p/TGFBR2 axis to affect the p38 MAPK/NF-κB pathway.

Gan, Lihong; Zheng, Li; Yao, Ling; Lei, Ling; Huang, Yaqin; Zeng, Zhiping; Fang, Nian.

Afiliação

Gan L; Third Clinical Medical College, Nanchang University, Nanchang, China; Department of Gastroenterology, The First Hospital of Nanchang (The Third Affiliated Hospital of Nanchang University), Nanchang, China.
Zheng L; Department of Gastroenterology, The First Hospital of Nanchang (The Third Affiliated Hospital of Nanchang University), Nanchang, China.
Yao L; Department of Gastroenterology, The First Hospital of Nanchang (The Third Affiliated Hospital of Nanchang University), Nanchang, China.
Lei L; Department of Gastroenterology, The First Hospital of Nanchang (The Third Affiliated Hospital of Nanchang University), Nanchang, China.
Huang Y; Department of Gastroenterology, The First Hospital of Nanchang (The Third Affiliated Hospital of Nanchang University), Nanchang, China.
Zeng Z; Department of Gastroenterology, The First Hospital of Nanchang (The Third Affiliated Hospital of Nanchang University), Nanchang, China.
Fang N; Third Clinical Medical College, Nanchang University, Nanchang, China; Department of Gastroenterology, The First Hospital of Nanchang (The Third Affiliated Hospital of Nanchang University), Nanchang, China. Electronic address: Fangnian0807@163.com.

Cytokine ; 172: 156386, 2023 12.

Article em En | MEDLINE | ID: mdl-37852157

Assuntos

Exossomos; Células-Tronco Mesenquimais; MicroRNAs; Camundongos; Humanos; Animais; NF-kappa B/metabolismo; Fator de Crescimento Transformador beta1; Receptor do Fator de Crescimento Transformador beta Tipo II/genética; Exossomos/metabolismo; Proteínas Quinases p38 Ativadas por Mitógeno; Cirrose Hepática/genética; Cirrose Hepática/terapia; Células-Tronco Mesenquimais/metabolismo; Fibrose; Colágeno; MicroRNAs/genética; RNA Mensageiro; Peso Corporal

Palavras-chave

Adipose-derived mesenchymal stem cells; CCl(4); Exosomes; LX-2 cells; Liver fibrosis; TGF-ß1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Exossomos / Células-Tronco Mesenquimais Limite: Animals / Humans Idioma: En Revista: Cytokine Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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