Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to Î³-Globin Gene Promoter Sequences.

Finotti, Alessia; Gasparello, Jessica; Zuccato, Cristina; Cosenza, Lucia Carmela; Fabbri, Enrica; Bianchi, Nicoletta; Gambari, Roberto

Finotti, Alessia; Gasparello, Jessica; Zuccato, Cristina; Cosenza, Lucia Carmela; Fabbri, Enrica; Bianchi, Nicoletta; Gambari, Roberto.

Afiliação

Finotti A; Department of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, Ferrara University, 44121 Ferrara, Italy.
Gasparello J; Department of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, Ferrara University, 44121 Ferrara, Italy.
Zuccato C; Department of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, Ferrara University, 44121 Ferrara, Italy.
Cosenza LC; Department of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, Ferrara University, 44121 Ferrara, Italy.
Fabbri E; Department of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, Ferrara University, 44121 Ferrara, Italy.
Bianchi N; Department of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, Ferrara University, 44121 Ferrara, Italy.
Gambari R; Department of Translational Medicine and for Romagna, Ferrara University, 44121 Ferrara, Italy.

Genes (Basel) ; 14(10)2023 10 11.

Article em En | MEDLINE | ID: mdl-37895276

Assuntos

Talassemia beta; gama-Globinas; Humanos; gama-Globinas/genética; gama-Globinas/metabolismo; Talassemia beta/genética; Plicamicina/farmacologia; Proteínas Repressoras/genética; Fatores de Transcrição/genética; Hemoglobina Fetal/genética; Hemoglobina Fetal/metabolismo; Expressão Gênica; Fatores de Transcrição Kruppel-Like/genética

Palavras-chave

BCL11A; HbF inducers; fetal hemoglobin; globin genes; mithramycin; transcription; ß-thalassemia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Talassemia beta / Gama-Globinas Limite: Humans Idioma: En Revista: Genes (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália

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