Discovery of 14-3-3 PPI Stabilizers by Extension of an Amidine-Substituted Thiophene Fragment.

Wu, Qi; Centorrino, Federica; Guillory, Xavier; Wolter, Madita; Ottmann, Christian; Cossar, Peter J; Brunsveld, Luc

Wu, Qi; Centorrino, Federica; Guillory, Xavier; Wolter, Madita; Ottmann, Christian; Cossar, Peter J; Brunsveld, Luc.

Afiliação

Wu Q; Laboratory of Chemical Biology, Department of Biomedical Engineering and, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands.
Centorrino F; Laboratory of Chemical Biology, Department of Biomedical Engineering and, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands.
Guillory X; Laboratory of Chemical Biology, Department of Biomedical Engineering and, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands.
Wolter M; Laboratory of Chemical Biology, Department of Biomedical Engineering and, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands.
Ottmann C; Laboratory of Chemical Biology, Department of Biomedical Engineering and, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands.
Cossar PJ; Laboratory of Chemical Biology, Department of Biomedical Engineering and, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands.
Brunsveld L; Laboratory of Chemical Biology, Department of Biomedical Engineering and, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands.

Chembiochem ; 25(1): e202300636, 2024 01 02.

Article em En | MEDLINE | ID: mdl-37902676

Assuntos

Proteínas 14-3-3; Receptor alfa de Estrogênio; Proteínas 14-3-3/química; Ligação Proteica; Descoberta de Drogas/métodos; Relação Estrutura-Atividade

Palavras-chave

14-3-3; Erα; Fragment; Molecular Glue; PPI Stabilizer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas 14-3-3 / Receptor alfa de Estrogênio Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Holanda

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