Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-&#954;B signaling pathway in aged mice.

Qian, Haitao; Gao, Fei; Wu, Xuyang; Lin, Daoyi; Huang, Yongxin; Chen, Andi; Deng, Jianhui; Gong, Cansheng; Chen, Xiaohui; Zheng, Xiaochun

Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice.

Qian, Haitao; Gao, Fei; Wu, Xuyang; Lin, Daoyi; Huang, Yongxin; Chen, Andi; Deng, Jianhui; Gong, Cansheng; Chen, Xiaohui; Zheng, Xiaochun.

Afiliação

Qian H; Shengli Clinical Medical College of Fujian Medical University, Department of Anesthesiology, Fujian Provincial Hospital, Fuzhou, China.
Gao F; Shengli Clinical Medical College of Fujian Medical University, Department of Anesthesiology, Fujian Provincial Hospital, Fuzhou, China.
Wu X; College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Lin D; Shengli Clinical Medical College of Fujian Medical University, Department of Anesthesiology, Fujian Provincial Hospital, Fuzhou, China.
Huang Y; Shengli Clinical Medical College of Fujian Medical University, Department of Anesthesiology, Fujian Provincial Hospital, Fuzhou, China.
Chen A; Shengli Clinical Medical College of Fujian Medical University, Department of Anesthesiology, Fujian Provincial Hospital, Fuzhou, China.
Deng J; Shengli Clinical Medical College of Fujian Medical University, Department of Anesthesiology, Fujian Provincial Hospital, Fuzhou, China.
Gong C; Shengli Clinical Medical College of Fujian Medical University, Department of Anesthesiology, Fujian Provincial Hospital, Fuzhou, China.
Chen X; Shengli Clinical Medical College of Fujian Medical University, Department of Anesthesiology, Fujian Provincial Hospital, Fuzhou, China. chenxh@fjmu.edu.cn.
Zheng X; Shengli Clinical Medical College of Fujian Medical University, Department of Anesthesiology, Fujian Provincial Hospital, Fuzhou, China. zhengxiaochun7766@163.com.

Inflamm Res ; 72(12): 2127-2144, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37902837

Assuntos

NF-kappa B; Complicações Cognitivas Pós-Operatórias; Animais; Camundongos; Interleucina-6/metabolismo; Microglia/metabolismo; Doenças Neuroinflamatórias; NF-kappa B/metabolismo; Fosfatidilinositol 3-Quinase; Fosfatidilinositol 3-Quinases/metabolismo; Complicações Cognitivas Pós-Operatórias/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais

Palavras-chave

Akt; CD200; CD200R1; Microglia polarization; NF-κB; Neuroinflammation; PI3K; POCD

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Complicações Cognitivas Pós-Operatórias Limite: Animals Idioma: En Revista: Inflamm Res Assunto da revista: ALERGIA E IMUNOLOGIA / PATOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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