Detection of cellular traction forces via the force-triggered Cas12a-mediated catalytic cleavage of a fluorogenic reporter strand.

Duan, Yuxin; Szlam, Fania; Hu, Yuesong; Chen, Wenchun; Li, Renhao; Ke, Yonggang; Sniecinski, Roman; Salaita, Khalid

Duan, Yuxin; Szlam, Fania; Hu, Yuesong; Chen, Wenchun; Li, Renhao; Ke, Yonggang; Sniecinski, Roman; Salaita, Khalid.

Afiliação

Duan Y; Department of Chemistry, Emory University, Atlanta, GA, USA.
Szlam F; Department of Anesthesiology, School of Medicine, Emory University, Atlanta, GA, USA.
Hu Y; Department of Chemistry, Emory University, Atlanta, GA, USA.
Chen W; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Departments of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.
Li R; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Departments of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.
Ke Y; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Sniecinski R; Department of Anesthesiology, School of Medicine, Emory University, Atlanta, GA, USA. rsnieci@emory.edu.
Salaita K; Department of Chemistry, Emory University, Atlanta, GA, USA. k.salaita@emory.edu.

Nat Biomed Eng ; 7(11): 1404-1418, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37957275

Assuntos

Sistemas CRISPR-Cas; Tração; Humanos; Adesão Celular/fisiologia; Proteínas; Proteínas de Transporte

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tração / Sistemas CRISPR-Cas Limite: Humans Idioma: En Revista: Nat Biomed Eng Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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